SCHEMBL29909065

SCHEMBL29909065

CN(c1cncc(Br)n1)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 10/20 0.36
FNTA P49354 1/20 0.35
FNTB P49356 1/20 0.35
PRMT5 O14744 4/20 0.34
CYP3A4 P08684 1/20 0.34
HRH4 Q9H3N8 2/20 0.34
CYP1A2 P05177 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
HRH3 Q9Y5N1 1/20 0.31
PARP15 Q460N3 1/20 0.30
TNKS2 Q9H2K2 1/20 0.30
PARP2 Q9UGN5 1/20 0.30
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577239 1.00 MAT2A (0.36) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL23601277 0.86 MAT2A (0.36) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL23577253 0.80 ALPL (0.38) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL23601458 0.80 MAT2A (0.36) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL23601712 0.79 MAT2A (0.36) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL30095584 0.78 MAT2A (0.62) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL24808619 0.78 MAT2A (0.62) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL23576994 0.78 MAT2A (0.35) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL29909194 0.78 MAT2A (0.35) MAT2AFNTAFNTBPRMT5CYP3A4
SCHEMBL23577499 0.78 CSF1R (0.44) MAT2APRMT5HRH4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 CN disclosed
CN-115362003-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2022-11-18 CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed