Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23577227 | 1.00 | HTT (0.55) | HTTKMT2AKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL9001629 | 0.85 | KMT2A (0.62) | HTTKMT2AKDM4EHSD17B2HSD17B1 | |
| SCHEMBL4181087 | 0.80 | KMT2A (0.57) | HTTKMT2AKDM4EHSD17B2HSD17B1 | |
| SCHEMBL8311376 | 0.80 | ALDH1A1 (0.42) | KMT2AKDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL493114 | 0.79 | KMT2A (0.75) | HTTKMT2AKDM4ERAB9AKDM1A | |
| SCHEMBL18780858 | 0.79 | KMT2A (0.56) | HTTKMT2AKDM4EHSD17B2HSD17B1 | |
| SCHEMBL20057572 | 0.79 | MEN1 (0.41) | KMT2ASMN1; SMN2 | |
| SCHEMBL10212283 | 0.79 | HSD17B2 (0.72) | HTTKMT2AKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL29940968 | 0.79 | HSD17B2 (0.72) | HTTKMT2AKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL18780868 | 0.78 | KMT2A (0.55) | HTTKMT2AKDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| CN-115362003-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2022-11-18 | — | — | CN | disclosed |
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |