SCHEMBL29909337

SCHEMBL29909337

CN(c1cccc(C#CC2(C)CC2)c1)c1nc2nnc(Cl)n2c2ccc(F)cc12

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.34
MAP3K14 Q99558 1/20 0.33
GRM5 P41594 2/20 0.31
DHODH Q02127 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29909261 0.85 ABCG2 (0.32) ABCG2
SCHEMBL29909076 0.84 GRM5 (0.34) ABCG2GRM5
SCHEMBL29909252 0.83 ABCG2 (0.45) ABCG2DHODH
SCHEMBL29909871 0.82 ABCG2 (0.40) ABCG2DHODH
SCHEMBL29909056 0.81 ABCG2 (0.30) ABCG2
SCHEMBL24721236 0.80 PTAFR (0.35) MAP3K14GRM5
SCHEMBL29909393 0.80 PTAFR (0.35) MAP3K14GRM5
SCHEMBL29909647 0.79 ABCG2 (0.30) ABCG2
SCHEMBL29909288 0.78 MAP3K14 (0.30) MAP3K14
SCHEMBL23577275 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed