SCHEMBL29909408

SCHEMBL29909408

N/N=c1/nc(N(CC2CC2)c2cccc(Br)c2)c2ccc(Cl)cc2[nH]1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.33
MAT2A P31153 4/20 0.33
PTGES O14684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29210688 1.00 IDO1 (0.33) IDO1MAT2APTGES
SCHEMBL30013536 1.00 IDO1 (0.33) IDO1MAT2APTGES
SCHEMBL23576815 1.00 IDO1 (0.33) IDO1MAT2APTGES
SCHEMBL23601305 0.86 MAT2A (0.42) MAT2APTGES
SCHEMBL30146701 0.81 EGFR (0.42) MAT2A
SCHEMBL23601321 0.81 EGFR (0.42) MAT2A
SCHEMBL29141395 0.81 EGFR (0.42) MAT2A
SCHEMBL23602020 0.77 ESR1 (0.32)
SCHEMBL23577594 0.74 MAPT (0.32) MAT2A
SCHEMBL29909555 0.74 MAPT (0.32) MAT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 CN disclosed
CN-115362003-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2022-11-18 CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed