Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29141395 | 1.00 | EGFR (0.42) | EGFRKDRMAT2APDGFRBGRM4 | |
| SCHEMBL23601321 | 1.00 | EGFR (0.42) | EGFRKDRMAT2APDGFRBGRM4 | |
| SCHEMBL30013725 | 0.88 | EGFR (0.43) | EGFRKDRPDGFRBGRM4RXRA | |
| SCHEMBL29909002 | 0.88 | EGFR (0.43) | EGFRKDRPDGFRBGRM4RXRA | |
| SCHEMBL23577040 | 0.88 | EGFR (0.43) | EGFRKDRPDGFRBGRM4RXRA | |
| SCHEMBL29210686 | 0.88 | EGFR (0.43) | EGFRKDRPDGFRBGRM4RXRA | |
| SCHEMBL23601305 | 0.86 | MAT2A (0.42) | EGFRKDRMAT2APDGFRB | |
| SCHEMBL23577087 | 0.85 | EGFR (0.41) | EGFRKDRPDGFRBRXRARXRB | |
| SCHEMBL29909240 | 0.85 | EGFR (0.41) | EGFRKDRPDGFRBRXRARXRB | |
| SCHEMBL30013226 | 0.85 | EGFR (0.41) | EGFRKDRPDGFRBRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359413-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117396478-A | Diacylglycerol kinase modulating compounds | 吉利德科学公司 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022271650-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-29 | — | — | WO | disclosed |