Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19089348 | 1.00 | HTR6 (0.39) | HTR6HTR2BRAPGEF4CHRNB4CHRNA3 | |
| SCHEMBL463544 | 0.82 | RAPGEF4 (0.44) | RAPGEF4 | |
| SCHEMBL1109742 | 0.82 | HTR6 (0.44) | HTR6RAPGEF4 | |
| SCHEMBL5506973 | 0.82 | RAPGEF4 (0.39) | HTR6RAPGEF4 | |
| SCHEMBL14895190 | 0.76 | HTR2B (0.39) | HTR2BCHRNB4CHRNA3MAPTHTT | |
| SCHEMBL19089354 | 0.76 | HTR2B (0.36) | HTR2BCHRNB4CHRNA3MAPTHTT | |
| SCHEMBL31373114 | 0.76 | HTR2B (0.39) | HTR2BCHRNB4CHRNA3MAPTHTT | |
| SCHEMBL21240055 | 0.76 | HTR2B (0.33) | HTR2BRAPGEF4 | |
| SCHEMBL12684720 | 0.76 | TDP1 (0.37) | HTR2BRAPGEF4CHRNB4CHRNA3HTT | |
| SCHEMBL16181574 | 0.73 | RAPGEF4 (0.48) | RAPGEF4MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359413-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022271650-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |