SCHEMBL29909653

SCHEMBL29909653

C#CC(C)(O)Cc1cc(F)cc(N(C)c2nc3nncn3c3cc(Cl)ccc23)c1

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.31
MAT2A P31153 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29909773 0.88
SCHEMBL29909515 0.88 MAPT (0.33) SMN1; SMN2MAT2AMAPT
SCHEMBL23601986 0.84 SMN1; SMN2 (0.32) SMN1; SMN2MAT2AMAPT
SCHEMBL23601865 0.81 SMN1; SMN2 (0.32) SMN1; SMN2
SCHEMBL23601647 0.81 TNIK (0.31) MAT2A
SCHEMBL29909480 0.80 MAPT (0.34) SMN1; SMN2MAT2AMAPT
SCHEMBL23601004 0.80 MAT2A (0.36) SMN1; SMN2MAT2AMAPT
SCHEMBL23601775 0.79 MAT2A (0.31) MAT2A
SCHEMBL29909947 0.79
SCHEMBL23576693 0.79 MAT2A (0.35) SMN1; SMN2MAT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed