SCHEMBL29909830

SCHEMBL29909830

CN(c1cccc(-c2ccc(C3(CN)CC3)cc2)c1)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.34
FNTB P49356 1/20 0.34
SLC6A4 P31645 3/20 0.32
SLC6A3 Q01959 3/20 0.32
SLC6A2 P23975 1/20 0.32
DPP4 P27487 1/20 0.32
SRC P12931 1/20 0.31
TP53 P04637 2/20 0.31
MAPT P10636 2/20 0.31
MAT2A P31153 3/20 0.31
PRMT5 O14744 1/20 0.31
CYP1A2 P05177 1/20 0.31
PBK Q96KB5 1/20 0.31
HSD11B1 P28845 2/20 0.30
POLB P06746 1/20 0.30
NR1I2 O75469 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577586 1.00 FNTA (0.34) FNTAFNTBSLC6A4SLC6A3SLC6A2
SCHEMBL29909787 0.92 FNTA (0.33) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23578133 0.92 FNTA (0.33) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23576674 0.92 SLC6A4 (0.35) FNTAFNTBSLC6A4SLC6A3SLC6A2
SCHEMBL29909769 0.92 SLC6A4 (0.35) FNTAFNTBSLC6A4SLC6A3SLC6A2
SCHEMBL23576631 0.87 MCHR1 (0.39)
SCHEMBL29909768 0.87 FNTA (0.40) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23601235 0.87 FNTA (0.40) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23601231 0.85 ALDH1A1 (0.33) FNTAFNTBSRCMAT2AHSD11B1
SCHEMBL31169411 0.85 ALDH1A1 (0.33) FNTAFNTBSRCMAT2AHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12054490-B2 Diacylglycerol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2024-08-06 US disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12054490-B2 Diacylglycerol kinase modulating compounds DGKG, DGKB, DGKK FNTA 968/4885FNTB 743/4885SLC6A4 4602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.