Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23577063 | 1.00 | ABCG2 (0.38) | ABCG2PDE5AEGFRDHODHALDH1A1 | |
| SCHEMBL23576893 | 0.93 | MAPT (0.33) | ABCG2PDE5AEGFRDHODHALDH1A1 | |
| SCHEMBL29909005 | 0.93 | MAPT (0.33) | ABCG2PDE5AEGFRDHODHALDH1A1 | |
| SCHEMBL29909160 | 0.92 | ABCG2 (0.38) | ABCG2PDE5AEGFRDHODHADORA2A | |
| SCHEMBL23577162 | 0.92 | ABCG2 (0.38) | ABCG2PDE5AEGFRDHODHADORA2A | |
| SCHEMBL23600979 | 0.91 | EGFR (0.44) | PDE5AEGFRKDR | |
| SCHEMBL29909323 | 0.90 | TP53 (0.37) | EGFRALDH1A1KDRPDGFRB | |
| SCHEMBL23576965 | 0.90 | TP53 (0.37) | EGFRALDH1A1KDRPDGFRB | |
| SCHEMBL23578033 | 0.88 | PDE5A (0.44) | ABCG2PDE5ADHODHALDH1A1TSHR | |
| SCHEMBL23576628 | 0.87 | ABCG2 (0.38) | ABCG2PDE5AEGFRDHODHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |