Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Amprolium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.98 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.98 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CASP1 | P29466 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TKT | P29401 | 2/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amprolium Ion SCHEMBL362893 | 1.00 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL28047744 | 1.00 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL29737311 | 0.99 | KDM4E (1.00) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL204023 | 0.99 | KDM4E (1.00) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL363586 | 0.99 | KDM4E (0.95) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL29387363 | 0.99 | KDM4E (0.95) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL20659804 | 0.97 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL204024 | 0.97 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL1571391 | 0.93 | KDM4E (0.85) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL7107461 | 0.90 | KDM4E (0.83) | KDM4ESLC19A2USP2LMNACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260237-A | EGFR-degrading agents and related methods of use | 百济神州(北京)生物科技有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-110891952-B | Cucurbituril derivatives as oxygen carriers | 伯努瓦·普里厄 | 2022-10-11 | — | — | CN | disclosed |