Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Amprolium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.36 |
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.98 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.98 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CASP1 | P29466 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amprolium Ion SCHEMBL20659804 | 1.00 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL29737311 | 0.99 | KDM4E (1.00) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL204023 | 0.99 | KDM4E (1.00) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL363586 | 0.99 | KDM4E (0.95) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL29387363 | 0.99 | KDM4E (0.95) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL29910331 | 0.97 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL362893 | 0.97 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL28047744 | 0.97 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL7107461 | 0.92 | KDM4E (0.83) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL1571391 | 0.91 | KDM4E (0.85) | KDM4ESLC19A2USP2LMNACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 486 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025133679-A1 | COMPOUNDS AND COMPOSITION FOR DNA PROTECTION | ASSOCIAÇÃO PARA DESENVOLVIMENTO DO CENTRO ACADÉMICO DE INVESTIGAÇÃO E FORMAÇÃO BIOMÉDICA DO ALGARVE, AD-ABC (PT) | 2025-06-26 | — | — | WO | claimed |
| US-11978622-B2 | Aqueous and semi-aqueous cleaners for the removal of post-etch residues with tungsten and cobalt compatibility | ENTEGRIS, INC. (US) | 2024-05-07 | — | — | US | claimed |
| US-11626584-B2 | High capacity electrodes | SOUTH DAKOTA BOARD OF REGENTS (US) | 2023-04-11 | — | — | US | claimed |
| CN-110963509-B | Method for disposing waste residues generated in amprolium hydrochloride condensation procedure | 浙江大洋生物科技集团股份有限公司 | 2022-08-12 | — | — | CN | claimed |
| CN-114306343-A | Medicament for preventing and treating coccidiosis infection of cattle and sheep and preparation method thereof | 西宁市动物疫病预防控制中心(挂西宁市畜牧兽医站牌子) | 2022-04-12 | — | — | CN | claimed |
| EP-3920273-A1 | HIGH CAPACITY ELECTRODES | South Dakota Board of Regents (US) | 2021-12-08 | — | — | EP | claimed |
| US-11124746-B2 | Post CMP cleaning composition | ENTEGRIS, INC. (US) | 2021-09-21 | — | — | US | claimed |
| EP-2964725-B1 | COMPOSITIONS AND METHODS FOR SELECTIVELY ETCHING TITANIUM NITRIDE | ENTEGRIS INC (US) | 2021-06-23 | — | — | EP | claimed |
| US-20210184202-A1 | HIGH CAPACITY ELECTRODES | SOUTH DAKOTA BOARD OF REGENTS | 2021-06-17 | — | — | US | claimed |
| US-10950847-B2 | High capacity electrodes | SOUTH DAKOTA BOARD OF REGENTS (US) | 2021-03-16 | — | — | US | claimed |
| CN-102846618-A | A veterinary preparation for treating coccidiosis in poultry and its preparation method | WANG HONGTAO | 2013-01-02 | — | — | CN | claimed |
| CN-101843624-B | Method for preparing soluble powder for treating livestock/poultry coccidiosis | HENAN HEALTH STAR PHARMACEUTICAL CO LTD | 2012-01-04 | — | — | CN | claimed |
| CN-101843624-A | Method for preparing soluble powder for treating livestock/poultry coccidiosis | HENAN HEALTH STAR PHARMACEUTICAL CO LTD | 2010-09-29 | — | — | CN | claimed |
| CN-101766591-A | Method for preparing water-soluble ethopabate and application thereof | LUOYANG PU LIKE BIO ENGINEERIN | 2010-07-07 | — | — | CN | claimed |
| CN-100431515-C | Method for preparing additive of stable micronized medication | UNIV ZHEJIANG (CN) | 2008-11-12 | — | — | CN | claimed |
| CN-101181297-A | Pharmaceutical composition | DECHANG WANG (CN) | 2008-05-21 | — | — | CN | claimed |
| CN-101129390-A | Compound coccidiostat pharmaceutical formulation | QINGDAO CONTINENT INDUSTRY (CN) | 2008-02-27 | — | — | CN | claimed |
| CN-1827166-A | Animal medicine for resisting and treating poultry coccidiosis | ZHAO HENG (CN) | 2006-09-06 | — | — | CN | claimed |
| CN-1695589-A | Method for preparing additive of stable micronized medication | UNIV ZHEJIANG (CN) | 2005-11-16 | — | — | CN | claimed |
| CN-1386507-A | Compound antiparasitic medicine for fish or full-value feed containing antiparasitic medicine | WANG YUWAN (CN) | 2002-12-25 | — | — | CN | claimed |