Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Amprolium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.98 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.98 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CASP1 | P29466 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TKT | P29401 | 2/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amprolium Ion SCHEMBL28047744 | 1.00 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL29910331 | 1.00 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL29737311 | 0.99 | KDM4E (1.00) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL204023 | 0.99 | KDM4E (1.00) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL363586 | 0.99 | KDM4E (0.95) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL29387363 | 0.99 | KDM4E (0.95) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL20659804 | 0.97 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL204024 | 0.97 | KDM4E (0.98) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL1571391 | 0.93 | KDM4E (0.85) | KDM4ESLC19A2USP2LMNACASP1 | |
| Amprolium Ion SCHEMBL7107461 | 0.90 | KDM4E (0.83) | KDM4ESLC19A2USP2LMNACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2385 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026098621-A1 | ENGINEERED ANTIBODY WITH SITE-SPECIFIC CONJUGATION, ANTIBODY-DRUG CONJUGATE, AND APPLICATION THEREOF | 百力司康生物医药(杭州)有限公司 | 2026-05-15 | — | — | WO | claimed |
| US-20250288557-A1 | FORMULATION AND METHOD FOR TREATMENT OF INFECTIONS | VETERINARY PHARMACY CORP (US) | 2025-09-18 | — | — | US | claimed |
| WO-2025151711-A1 | NUCLEIC ACID VACCINES TARGETING METHANOGENS | Arkea Bio Corp. (US) | 2025-07-17 | — | — | WO | claimed |
| WO-2025151713-A1 | PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS | Arkea Bio Corp. (US) | 2025-07-17 | — | — | WO | claimed |
| US-20250222082-A1 | PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS | ARKEA BIO CORP (US) | 2025-07-10 | — | — | US | claimed |
| WO-2025128700-A1 | CELL-BASED VACCINES | Arkea Bio Corp. (US) | 2025-06-19 | — | — | WO | claimed |
| WO-2025085377-A1 | USE OF ZOALENE IN LIVESTOCK | ZOETIS SERVICES LLC (US) | 2025-04-24 | — | — | WO | claimed |
| WO-2024138230-A1 | FORMULATION AND METHOD FOR TREATMENT OF INFECTIONS | VETERINARY PHARMACY CORPORATION (US) | 2024-06-27 | — | — | WO | claimed |
| US-11819535-B2 | Composition and methods for regulating extracellular matrix accumulation | UNIVERSITY HEALTH NETWORK (CA) | 2023-11-21 | — | — | US | claimed |
| US-20230265441-A1 | Aptamers That Bind Thiamine Analogs and Derivatives | MeiraGTx Gene Regulation Limited (GB) | 2023-08-24 | — | — | US | claimed |
| US-4861758-A | Coccidiocidal compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-29 | — | — | US | claimed |
| US-4855299-A | Coccidiocidal compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-08 | — | — | US | claimed |
| US-4824847-A | SYNERGISTIC MIXTURE CONTAINING LASALOCID A | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-04-25 | — | — | US | claimed |
| EP-0279290-A2 | Anticoccidial agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-24 | — | — | EP | claimed |
| EP-0268135-A2 | Coccidiocidal agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-05-25 | — | — | EP | claimed |
| EP-0267520-A2 | Coccidiocidal agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-05-18 | — | — | EP | claimed |
| EP-0246532-A1 | Coccidiocidal agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-11-25 | — | — | EP | claimed |
| US-4654325-A | Medicament for reducing nephrotoxicity caused by positively charged agents such as aminoglycosides and methods of use thereof | SELENKE WILLIAM M | 1987-03-31 | — | — | US | claimed |
| EP-0146738-A2 | Antimicrobial animal feed additive compositions | AMERICAN CYANAMID COMPANY (US) | 1985-07-03 | — | — | EP | claimed |
| US-4044133-A | FEED SUPPLEMENT, POULTRY, THIENO-PYRIDINE, OR FURO-PYRIDINE BASE N | MERCK & CO., INC. (US) | 1977-08-23 | — | — | US | claimed |