Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 9/20 | 0.34 |
| ▸ | HTR1A | P08908 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29434173 | 0.81 | P2RX4 (0.37) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL1198914 | 0.81 | P2RX4 (0.37) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| Hydrochloric Acid SCHEMBL29035745 | 0.79 | MEN1 (0.37) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| Iodide SCHEMBL27879086 | 0.79 | P2RX4 (0.36) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| Iodide SCHEMBL7101346 | 0.79 | P2RX4 (0.36) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| Iodide SCHEMBL30253496 | 0.79 | P2RX4 (0.36) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| Iodide SCHEMBL27895829 | 0.78 | MAPT (0.36) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL12013901 | 0.76 | HTR1A (0.36) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL27890223 | 0.74 | P2RX4 (0.33) | P2RX4HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL28221845 | 0.74 | P2RX4 (0.33) | P2RX4HTR1ADRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952380-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2024-04-09 | — | — | US | disclosed |
| US-20220267339-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2022-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220267339-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | P2RX4 4604/4885HTR1A 4590/4885DRD2 4790/4885 |
| US-11952380-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | P2RX4 4604/4885HTR1A 4590/4885DRD2 4790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.