Atractylochromene

Atractylochromene

SCHEMBL2991263

CC(C)=CCCC1(C)C=Cc2cc(O)cc(C)c2O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 2/20 1.00
▸ PTGS1 P23219 1/20 1.00
▸ NR1H4 Q96RI1 4/20 0.72
▸ BACE1 P56817 2/20 0.72
▸ MAPT P10636 3/20 0.54
▸ KMT2A Q03164 3/20 0.54
▸ GAA P10253 2/20 0.54
▸ NPSR1 Q6W5P4 2/20 0.54
▸ POLB P06746 1/20 0.54
▸ IDE P14735 1/20 0.54
▸ XBP1 P17861 1/20 0.54
▸ MEN1 O00255 2/20 0.51
▸ PNLIP P16233 1/20 0.51
▸ APP P05067 2/20 0.47
▸ BCHE P06276 3/20 0.46
▸ TRPA1 O75762 1/20 0.46
▸ LDHA P00338 1/20 0.46
▸ CNR1 P21554 1/20 0.46
▸ SLC6A2 P23975 1/20 0.46
▸ SLC6A4 P31645 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14212077 0.93 ALOX5 (0.87) ALOX5PTGS1NR1H4BACE1MAPT
SCHEMBL3434917 0.86 NR1H4 (0.78) ALOX5PTGS1NR1H4BACE1MAPT
(R)-Sargachromenol SCHEMBL10301178 0.85 NR1H4 (1.00) ALOX5PTGS1NR1H4BACE1APP
Tuberatolide B SCHEMBL38651892 0.81 NR1H4 (1.00) ALOX5PTGS1NR1H4BACE1MAPT
SCHEMBL10536246 0.80 ALOX5 (0.66) ALOX5PTGS1NR1H4BACE1MAPT
Cordiachromene A SCHEMBL16666262 0.79 PTGS1 (0.68) ALOX5PTGS1NR1H4BACE1MAPT
Cordiachromene A SCHEMBL16666288 0.79 PTGS1 (0.68) ALOX5PTGS1NR1H4BACE1MAPT
Cordiachromene A SCHEMBL9356402 0.79 PTGS1 (0.68) ALOX5PTGS1NR1H4BACE1MAPT
SCHEMBL14283918 0.77 ALOX5 (0.62) ALOX5PTGS1NR1H4BACE1MAPT
SCHEMBL10536271 0.75 PTGS1 (0.60) ALOX5PTGS1NR1H4BACE1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656178-A1 COSMETIC USE OF ATRACTYLODES LANCEA ROOT EXTRACT Provital, S.A. (ES) 2025-12-03 — — EP disclosed
US-20150150770-A1 METHODS OF TREATING SKIN TRACIE MARTYN INTERNATIONAL INC (US) 2015-06-04 — — US disclosed
US-20140155961-A1 METHODS OF TREATING SKIN Tracie Martyn International, Inc. (US) 2014-06-05 — — US disclosed
US-20100272790-A1 Methods of Treating Skin TRACIE MARTYN INTERNATIONAL, LLC (US) 2010-10-28 — — US disclosed
US-7776915-B2 Topical formulations and methods of use TRACIE MARTYN INTERNATIONAL, LLC (US) 2010-08-17 — — US disclosed
US-20060216251-A1 Topical formulations and methods of use TRACIE MARTYN INTERNATIONAL, LLC (US) 2006-09-28 — — US disclosed
US-20020192305-A1 Inflammatory mediation obtained from atractylodes lancea MONSANTO COMPANY 2002-12-19 — — US disclosed
CN-1362881-A Inflammatory mediation obtained from atractylodes lancea PHARMACIA CO (US) 2002-08-07 — — CN disclosed
WO-2000056348-A9 INFLAMMATORY MEDIATION OBTAINED FROM ATRACTYLODES LANCEA PHARMACIA CORP (US) 2002-06-27 — — WO disclosed
EP-1171142-A1 INFLAMMATORY MEDIATION OBTAINED FROM ATRACTYLODES LANCEA MONSANTO COMPANY (US) 2002-01-16 — — EP disclosed
US-20010006686-A1 INFLAMMATORY MEDIATION OBTAINED FROM ATRACTYLODES LANCEA MONSANTO COMPANY 2001-07-05 — — US disclosed
WO-2000056348-A1 INFLAMMATORY MEDIATION OBTAINED FROM ATRACTYLODES LANCEA PHARMACIA CORPORATION (US) 2000-09-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140155961-A1 METHODS OF TREATING SKIN CUTA, LIPA, DLAT ALOX5 89/4885PTGS1 2158/4885NR1H4 3403/4885
US-20100272790-A1 Methods of Treating Skin CUTA, LIPA, DLAT ALOX5 89/4885PTGS1 2158/4885NR1H4 3403/4885
US-20150150770-A1 METHODS OF TREATING SKIN CUTA, LIPA, DLAT ALOX5 89/4885PTGS1 2158/4885NR1H4 3403/4885
US-20060216251-A1 Topical formulations and methods of use CPT1B, SLC25A20, CPT1A ALOX5 133/4885PTGS1 1349/4885NR1H4 3934/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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