Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 12/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17882280 | 1.00 | RIPK1 (0.50) | RIPK1HDAC3HDAC6CES2CES1 | |
| SCHEMBL17874116 | 0.85 | RIPK1 (0.61) | RIPK1HDAC3HDAC6CES2CES1 | |
| SCHEMBL29912757 | 0.85 | RIPK1 (0.61) | RIPK1HDAC3HDAC6CES2CES1 | |
| SCHEMBL17882376 | 0.76 | RIPK1 (0.61) | RIPK1HDAC3HDAC6CES2CES1 | |
| SCHEMBL29912817 | 0.76 | RIPK1 (0.61) | RIPK1HDAC3HDAC6CES2CES1 | |
| SCHEMBL29046387 | 0.74 | RIPK1 (0.66) | RIPK1HDAC3HDAC6CES2CES1 | |
| SCHEMBL17882382 | 0.71 | RIPK1 (0.67) | RIPK1KDM4EALDH1A1 | |
| SCHEMBL29912774 | 0.71 | RIPK1 (0.67) | RIPK1KDM4EALDH1A1 | |
| SCHEMBL13036148 | 0.70 | LMNA (0.37) | LMNAALDH1A1 | |
| SCHEMBL14013300 | 0.69 | RIPK1 (0.46) | RIPK1HDAC3HDAC6CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197098-B | Cell necrosis inhibitor | 北京生命科学研究所 | 2023-08-08 | — | — | CN | disclosed |
| CN-115197098-A | Cell necrosis inhibitor | 北京生命科学研究所 | 2022-10-18 | — | — | CN | disclosed |
| CN-107108467-B | Cell necrosis inhibitor | 北京生命科学研究所 | 2022-08-19 | — | — | CN | disclosed |