Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12640806 | 1.00 | RIPK1 (0.40) | RIPK1CES2CES1CHRM4ROCK2 | |
| SCHEMBL13452521 | 0.79 | SLC6A4 (0.41) | RIPK1CHRM4ROCK2ROCK1HTR2A | |
| SCHEMBL29912949 | 0.79 | SLC6A4 (0.41) | RIPK1CHRM4ROCK2ROCK1HTR2A | |
| SCHEMBL29912778 | 0.77 | USP28 (0.40) | RIPK1CES2CES1ALDH1A1SLC6A4 | |
| SCHEMBL4574283 | 0.77 | USP28 (0.40) | RIPK1CES2CES1ALDH1A1SLC6A4 | |
| SCHEMBL10061120 | 0.77 | RIPK1 (0.42) | RIPK1CES2CES1 | |
| SCHEMBL12640870 | 0.77 | CHRM4 (0.36) | RIPK1CHRM4ROCK2ROCK1BACE1 | |
| SCHEMBL10195688 | 0.76 | RIPK1 (0.49) | RIPK1CES2CES1CHRM4 | |
| SCHEMBL18588922 | 0.76 | HTR2A (0.44) | RIPK1HTR2AHTR2CSLC6A4 | |
| SCHEMBL13973319 | 0.76 | IDO1 (0.46) | RIPK1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197098-B | Cell necrosis inhibitor | 北京生命科学研究所 | 2023-08-08 | — | — | CN | disclosed |
| CN-115197098-A | Cell necrosis inhibitor | 北京生命科学研究所 | 2022-10-18 | — | — | CN | disclosed |
| CN-107108467-B | Cell necrosis inhibitor | 北京生命科学研究所 | 2022-08-19 | — | — | CN | disclosed |