Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2988124 | 0.84 | ALDH1A1 (0.43) | ALDH1A1TP53LMNAHTTMAPT | |
| SCHEMBL2989344 | 0.81 | ALDH1A1 (0.51) | ALDH1A1TP53LMNAHTTMAPT | |
| SCHEMBL30999151 | 0.81 | ALDH1A1 (0.42) | ALDH1A1TP53LMNAHTTMAPT | |
| SCHEMBL2997199 | 0.78 | ALDH1A1 (0.69) | ALDH1A1TP53LMNAHTTMAPT | |
| SCHEMBL2994923 | 0.72 | MAPT (0.40) | ALDH1A1TP53LMNAHTTMAPT | |
| SCHEMBL2795442 | 0.70 | ALDH1A1 (0.51) | ALDH1A1TP53LMNAHTTMAPT | |
| SCHEMBL30243505 | 0.68 | ALDH1A1 (0.47) | ALDH1A1TP53LMNAHTTMAPT | |
| SCHEMBL15897807 | 0.68 | CHRM3 (0.50) | ALDH1A1TP53LMNAHTTMAPT | |
| SCHEMBL24662663 | 0.68 | HDAC4 (0.40) | ALDH1A1GAAKMT2A | |
| SCHEMBL2986864 | 0.67 | ALDH1A1 (0.46) | ALDH1A1TP53LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776897-B2 | such as 3-[1-(5-chloro-2-thienyl)cyclopenty]-5,6,7,8,9,10-hexahydro [1,2,4]triazolo[4,3-a]azocine, having a strong 11 beta -hydroxysteroid dehydrogenase type 1inhibitory activity and exhibiting an excellent blood-glucose level-lowering action, used for the therapy of diabetes and insulin resistance | ASTELLAS PHARMA INC. (JP) | 2010-08-17 | — | — | US | disclosed |
| US-20070259854-A1 | Triazole Derivative or Salt Thereof | ASTELLAS PHARMA INC. (JP) | 2007-11-08 | — | — | US | disclosed |
| EP-1790641-A1 | TRIAZOLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259854-A1 | Triazole Derivative or Salt Thereof | HSD11B1, HSD11B2, HSD3B1 | ALDH1A1 288/4885TP53 4289/4885LMNA 4230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.