Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681271 | 1.00 | NOTUM (0.53) | NOTUMRORCGPR119MEN1KMT2A | |
| SCHEMBL27926423 | 0.82 | RORC (0.46) | NOTUMRORCGPR119 | |
| SCHEMBL27337897 | 0.82 | RORC (0.44) | NOTUMRORCGPR119MEN1KMT2A | |
| SCHEMBL31319987 | 0.80 | NOTUM (0.43) | NOTUMRORCNPY5R | |
| SCHEMBL23507300 | 0.78 | NOTUM (0.56) | NOTUMMEN1KMT2ALMNAHDAC1 | |
| SCHEMBL29157649 | 0.76 | LSS (0.55) | NOTUMGPR119MEN1KMT2ALSS | |
| SCHEMBL29157650 | 0.76 | LSS (0.55) | NOTUMGPR119MEN1KMT2ALSS | |
| SCHEMBL29157657 | 0.76 | LSS (0.55) | NOTUMGPR119MEN1KMT2ALSS | |
| SCHEMBL29914435 | 0.75 | ACVR1 (0.41) | RORCGPR119PTGS2 | |
| SCHEMBL29914621 | 0.75 | ACVR1 (0.41) | RORCGPR119PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |