Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.46 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL555326 | 1.00 | ATM (0.56) | ATMPARP1KDM4ECYP1A2ATAD2 | |
| SCHEMBL30283346 | 0.79 | PARP1 (0.58) | ATMPARP1KDM4EROCK1 | |
| SCHEMBL12241457 | 0.77 | PARP1 (0.49) | ATMPARP1KDM4EATAD2ALDH1A1 | |
| SCHEMBL12440976 | 0.77 | PARP1 (0.49) | ATMPARP1KDM4ECYP1A2ATAD2 | |
| SCHEMBL12286658 | 0.77 | PARP1 (0.49) | ATMPARP1KDM4ECYP1A2ATAD2 | |
| SCHEMBL12219900 | 0.75 | TBK1 (0.40) | KDM4EALDH1A1LMNAHPGDRECQL | |
| SCHEMBL11816663 | 0.74 | PARP1 (0.52) | PARP1KDM4ETNKS2CYP2C19ALDH1A1 | |
| SCHEMBL29488098 | 0.74 | PARP1 (0.60) | PARP1KDM4ECYP1A2ALDH1A1LMNA | |
| SCHEMBL832144 | 0.74 | PARP1 (0.60) | PARP1KDM4ECYP1A2ALDH1A1LMNA | |
| SCHEMBL24556549 | 0.74 | KDM4C (0.47) | PARP1ATAD2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330246-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | Ontario Institute for Cancer Research (OICR) (CA) | 2024-03-06 | — | — | EP | disclosed |
| CN-117597336-A | Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| WO-2022226665-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |