SCHEMBL3228523

SCHEMBL3228523

Cc1[nH]c2ccccc2c1Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.61
ALDH1A1 P00352 4/20 0.50
MAPT P10636 3/20 0.50
LMNA P02545 2/20 0.50
CYP3A4 P08684 1/20 0.50
GPR3 P46089 1/20 0.50
HSD17B10 Q99714 1/20 0.50
NPSR1 Q6W5P4 3/20 0.49
KMT2A Q03164 2/20 0.49
MITF O75030 1/20 0.49
RAB9A P51151 1/20 0.49
HTT P42858 2/20 0.48
TSHR P16473 1/20 0.48
KDM4E B2RXH2 2/20 0.47
POLB P06746 2/20 0.47
IMPDH2 P12268 1/20 0.47
HPGD P15428 1/20 0.47
GFER P55789 1/20 0.47
HTR6 P50406 1/20 0.46
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7162004 0.84 HTT (0.59) AHRALDH1A1MAPTLMNACYP3A4
SCHEMBL29420757 0.76 AHR (1.00) AHRALDH1A1MAPTLMNACYP3A4
SCHEMBL154593 0.76 AHR (1.00) AHRALDH1A1MAPTLMNACYP3A4
SCHEMBL1021516 0.76 ALDH1A1 (0.55) AHRALDH1A1MAPTLMNAGPR3
SCHEMBL8591132 0.76 KDM1A (0.69) AHRALDH1A1MAPTCYP3A4GPR3
SCHEMBL14339328 0.75 DAO (0.58) AHRALDH1A1MAPTLMNAGPR3
SCHEMBL1757631 0.74 AHR (0.64) AHRALDH1A1MAPTLMNACYP3A4
SCHEMBL30981725 0.74 ALDH1A1 (0.52) AHRALDH1A1MAPTLMNAGPR3
SCHEMBL24201871 0.74 HSD17B10 (0.50) ALDH1A1MAPTLMNAHSD17B10KMT2A
SCHEMBL20611959 0.74 KIF11 (0.52) MAPTLMNAMITFRAB9AKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118184567-B Process for preparing 3-haloindole derivatives 常州工程职业技术学院 2025-02-18 CN disclosed
CN-118184567-A Process for preparing 3-haloindole derivatives 常州工程职业技术学院 2024-06-14 CN disclosed
US-20220033376-A1 ESTROGEN RECEPTOR ANTAGONIST CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2022-02-03 US disclosed
CN-215026074-U Device for rectifying and purifying p-chloromethyl indole 山东物竞新材料科技有限公司 2021-12-07 CN disclosed
EP-3889133-A1 ESTROGEN RECEPTOR ANTAGONIST Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) 2021-10-06 EP disclosed
US-20200397901-A1 PHOTORESPONSIVE SMOOTHENED LIGAND THE UNIVERSITY OF TOKYO (JP) 2020-12-24 US disclosed
WO-2020125640-A1 ESTROGEN RECEPTOR ANTAGONIST 正大天晴药业集团股份有限公司 2020-06-25 WO disclosed
US-20100069244-A1 Pyridine Compounds for Combating Pests BASF SE (DE) 2010-03-18 US disclosed
US-7067656-B2 Sulfamoyl compounds and agricultural and horticultural fungicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2006-06-27 US disclosed
US-20040143116-A1 Sulfamoyl compounds and agricultural and horticultural fungicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2004-07-22 US disclosed
US-6620812-B2 Such as 1-(N,N-dimethylsulfamoyl)-3-(2-methyl-3-chloroindol-1-yl)sulfonyl-1,2,4 -triazole NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2003-09-16 US disclosed
US-20020103243-A1 Sulfamoyl compounds and agricultural and horticultural fungicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2002-08-01 US disclosed
US-6350748-B1 1-(SULFAMOYL)-3-(SULFONYL)-1,2,4-TRIAZOLE DERIVATIVES NISSAN CHEMICAL INDUSTRIES LTD. (JP) 2002-02-26 US disclosed
EP-1031571-A1 SULFAMOYL COMPOUNDS AND AGRICULTURAL OR HORTICULTURAL BACTERICIDE Nissan Chemical Industries, Ltd. (JP) 2000-08-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020103243-A1 Sulfamoyl compounds and agricultural and horticultural fungicides SULT1E1, STS, TST AHR 230/4885ALDH1A1 487/4885MAPT 4801/4885
US-20040143116-A1 Sulfamoyl compounds and agricultural and horticultural fungicides SULT1E1, STS, SULT2A1 AHR 303/4885ALDH1A1 518/4885MAPT 4790/4885
US-20200397901-A1 PHOTORESPONSIVE SMOOTHENED LIGAND SMO, GLI1, SHH AHR 55/4885ALDH1A1 646/4885MAPT 4450/4885
US-20220033376-A1 ESTROGEN RECEPTOR ANTAGONIST ESR1, GPER1, ESR2 AHR 145/4885ALDH1A1 1381/4885MAPT 3804/4885
US-20100069244-A1 Pyridine Compounds for Combating Pests CHRM1, PRDX1, CHRM2 AHR 977/4885ALDH1A1 1958/4885MAPT 4388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.