Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 9/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 6/20 | 0.38 |
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19121210 | 0.79 | TRPA1 (0.44) | TRPA1KMT2A | |
| SCHEMBL3634671 | 0.75 | HDAC1 (0.41) | TRPA1KMT2A | |
| SCHEMBL7354878 | 0.73 | CA2 (0.59) | PTGES2CA1CA2CA9CA12 | |
| SCHEMBL11660041 | 0.73 | TRPA1 (0.43) | TRPA1KMT2A | |
| SCHEMBL30681712 | 0.72 | PTGES2 (0.47) | PTGES2CA1CA2CA9CA12 | |
| SCHEMBL30681713 | 0.72 | PTGES2 (0.47) | PTGES2CA1CA2CA9CA12 | |
| SCHEMBL17384694 | 0.72 | PTGES2 (0.47) | PTGES2CA1CA2CA9CA12 | |
| SCHEMBL18209561 | 0.71 | PTGES2 (0.44) | PTGES2CA1CA2CA9CA12 | |
| SCHEMBL29400968 | 0.70 | HPGD (0.43) | CA1CA2CA9CA12CISD1 | |
| SCHEMBL2778937 | 0.70 | PTGES2 (0.44) | PTGES2CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2147915-B1 | New cycloalkylated benzothiadiazine derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-09-15 | — | — | EP | disclosed |