Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2429656 | 1.00 | HTR2A (0.49) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| SCHEMBL2426852 | 1.00 | HTR2A (0.49) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| Hydrochloric Acid SCHEMBL5968017 | 0.99 | HTR2A (0.48) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| Iodide SCHEMBL29454678 | 0.99 | HTR2A (0.48) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| SCHEMBL20012239 | 0.96 | GHSR (0.50) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| SCHEMBL11990452 | 0.96 | GHSR (0.50) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| SCHEMBL13688291 | 0.93 | HTR2A (0.42) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| SCHEMBL11969643 | 0.92 | HTR2A (0.53) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| SCHEMBL11990381 | 0.89 | DRD3 (0.54) | HTR2AHRH1KCNH2CHRM1DRD2 | |
| SCHEMBL5974183 | 0.86 | POLB (0.48) | HTR2AHRH1KCNH2CHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179114-A1 | S-Isomer of 2- piperidine and Other Dermal Anesthetic Agents | BRIDGE PHARMA, INC. (US) | 2010-07-15 | — | — | US | claimed |
| US-7718674-B2 | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine | BRIDGE PHARMA, INC. (US) | 2010-05-18 | — | — | US | claimed |
| US-20060079559-A1 | S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics | BRIDGE PHARMA, INC. (US) | 2006-04-13 | — | — | US | claimed |
| WO-2006036936-A2 | THE S-ISOMER OF 2-{2-[N-(2-INDANYL)-N-PHENYLAMINO]ETHYL}PIPERIDINE AND OTHER DERMAL ANESTHETIC AGENTS | BRIDGE PHARMA, INC. (US) | 2006-04-06 | — | — | WO | claimed |
| EP-3363437-B1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | ENDO PHARMACEUTICALS SOLUTIONS (US) | 2021-07-28 | — | — | EP | disclosed |
| EP-2675787-B1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | ENDO PHARMACEUTICALS INC (US) | 2018-03-28 | — | — | EP | disclosed |
| US-9375423-B2 | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis | ASANA BIOSCIENCES, LLC (US) | 2016-06-28 | — | — | US | disclosed |
| US-9375423-B2 | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis | ASANA BIOSCIENCES, LLC (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150290182-A1 | USE OF AMINOINDANE COMPOUNDS IN TREATING OVERACTIVE BLADDER AND INTERSTITIAL CYSTITIS | ASANA BIOSCIENCES, LLC (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150290182-A1 | USE OF AMINOINDANE COMPOUNDS IN TREATING OVERACTIVE BLADDER AND INTERSTITIAL CYSTITIS | ASANA BIOSCIENCES, LLC (US) | 2015-10-15 | — | — | US | disclosed |
| US-9044482-B2 | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis | ASANA BIOSCIENCES, LLC (US) | 2015-06-02 | — | — | US | disclosed |
| US-9044482-B2 | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis | ASANA BIOSCIENCES, LLC (US) | 2015-06-02 | — | — | US | disclosed |
| US-20100179114-A1 | S-Isomer of 2- piperidine and Other Dermal Anesthetic Agents | BRIDGE PHARMA, INC. (US) | 2010-07-15 | — | — | US | disclosed |
| US-20100179114-A1 | S-Isomer of 2- piperidine and Other Dermal Anesthetic Agents | BRIDGE PHARMA, INC. (US) | 2010-07-15 | — | — | US | disclosed |
| US-20100179114-A1 | S-Isomer of 2- piperidine and Other Dermal Anesthetic Agents | BRIDGE PHARMA, INC. (US) | 2010-07-15 | — | — | US | disclosed |
| US-7718674-B2 | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine | BRIDGE PHARMA, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718674-B2 | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine | BRIDGE PHARMA, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718674-B2 | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine | BRIDGE PHARMA, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20060079559-A1 | S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics | BRIDGE PHARMA, INC. (US) | 2006-04-13 | — | — | US | disclosed |
| WO-2006036936-A2 | THE S-ISOMER OF 2-{2-[N-(2-INDANYL)-N-PHENYLAMINO]ETHYL}PIPERIDINE AND OTHER DERMAL ANESTHETIC AGENTS | BRIDGE PHARMA, INC. (US) | 2006-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179114-A1 | S-Isomer of 2- piperidine and Other Dermal Anesthetic Agents | TRPA1, OPRL1, OPRM1 | HTR2A 54/4885HRH1 94/4885KCNH2 288/4885 |
| US-20060079559-A1 | S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics | OPRL1, TRPA1, OPRM1 | HTR2A 17/4885HRH1 180/4885KCNH2 165/4885 |
| US-20150290182-A1 | USE OF AMINOINDANE COMPOUNDS IN TREATING OVERACTIVE BLADDER AND INTERSTITIAL CYSTITIS | IDO1, IDO2, SLC1A2 | HTR2A 305/4885HRH1 310/4885KCNH2 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.