Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 6/20 | 0.37 |
| ▸ | MET | P08581 | 4/20 | 0.37 |
| ▸ | STAT6 | P42226 | 3/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3006532 | 0.87 | INSR (0.40) | INSRMETSTAT6ALKJAK2 | |
| SCHEMBL2991920 | 0.85 | MET (0.49) | INSRMETMAP4K1ALKJAK2 | |
| SCHEMBL2991913 | 0.82 | MET (0.57) | INSRMETMAP4K1ALKMAPK8 | |
| SCHEMBL2991917 | 0.82 | MET (0.57) | INSRMETMAP4K1ALKMAPK8 | |
| SCHEMBL3007400 | 0.72 | INSR (0.58) | INSRMETSTAT6ALKMAPK8 | |
| SCHEMBL3006537 | 0.71 | MET (0.51) | INSRMETMAP4K1ALKJAK2 | |
| SCHEMBL886121 | 0.70 | MET (0.75) | INSRMETMAP4K1ALK | |
| SCHEMBL886120 | 0.70 | MET (0.75) | INSRMETMAP4K1ALK | |
| SCHEMBL3006529 | 0.68 | MET (0.60) | INSRMETMAP4K1ALKMAPK8 | |
| SCHEMBL3005454 | 0.67 | MET (0.61) | INSRMETMAP4K1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |