Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.57 |
| ▸ | INSR | P06213 | 4/20 | 0.57 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991913 | 1.00 | MET (0.57) | METINSRMAP4K1ALKPTK2 | |
| SCHEMBL886121 | 0.87 | MET (0.75) | METINSRMAP4K1ALK | |
| SCHEMBL886120 | 0.87 | MET (0.75) | METINSRMAP4K1ALK | |
| SCHEMBL3006529 | 0.87 | MET (0.60) | METINSRMAP4K1ALKPTK2 | |
| SCHEMBL2991920 | 0.83 | MET (0.49) | METINSRMAP4K1ALKJAK2 | |
| SCHEMBL2991915 | 0.82 | INSR (0.37) | METINSRMAP4K1ALKJAK2 | |
| SCHEMBL886250 | 0.78 | MET (0.74) | METINSRMAP4K1ALKPTK2 | |
| SCHEMBL885567 | 0.78 | MET (0.74) | METINSRMAP4K1ALKPTK2 | |
| SCHEMBL885568 | 0.78 | MET (0.74) | METINSRMAP4K1ALKPTK2 | |
| SCHEMBL3005454 | 0.78 | MET (0.61) | METINSRMAP4K1ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |