Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 6/20 | 0.50 |
| ▸ | METTL14 | Q9HCE5 | 6/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 11/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 6/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23458922 | 1.00 | METTL3 (0.50) | METTL3METTL14HRH4DRD3SIGMAR1 | |
| Lithium SCHEMBL29919186 | 0.99 | METTL3 (0.49) | METTL3METTL14HRH4DRD3SIGMAR1 | |
| SCHEMBL31519271 | 0.87 | DRD3 (0.46) | METTL3METTL14HRH4DRD3SIGMAR1 | |
| SCHEMBL30811839 | 0.82 | HRH4 (0.47) | METTL3METTL14HRH4DRD3SIGMAR1 | |
| SCHEMBL25615716 | 0.81 | METTL3 (0.54) | METTL3METTL14HRH4DRD3SIGMAR1 | |
| SCHEMBL30837532 | 0.80 | HRH4 (0.69) | METTL3METTL14HRH4DRD3DRD2 | |
| SCHEMBL23482013 | 0.73 | LOXL2 (0.46) | — | |
| SCHEMBL23481977 | 0.71 | HRH3 (0.62) | METTL3METTL14SIGMAR1 | |
| SCHEMBL23481976 | 0.71 | METTL3 (0.51) | METTL3METTL14DRD3SIGMAR1DRD1 | |
| SCHEMBL29965877 | 0.71 | METTL3 (0.51) | METTL3METTL14DRD3SIGMAR1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069694-A1 | POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS | Storm Therapeutics Ltd (GB) | 2022-10-12 | — | — | EP | disclosed |
| CN-115151540-A | Polyheterocyclic compounds as METTL3 inhibitors | 风暴治疗有限公司 | 2022-10-04 | — | — | CN | disclosed |