Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 13/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19354353 | 0.82 | PDE1B (0.44) | PDE1BMAPTLMNAPDE2ASMN1; SMN2 | |
| SCHEMBL30678371 | 0.79 | PDE1B (0.42) | PDE1BSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL19354354 | 0.78 | PDE1B (0.42) | PDE1BMAPTLMNAPDE2ASMN1; SMN2 | |
| SCHEMBL15413896 | 0.77 | NOS1 (0.39) | PDE1BMAPTLMNATGFBR1KDM4E | |
| SCHEMBL15407268 | 0.77 | KDM4E (0.38) | PDE1BMAPTLMNAPDE2ATGFBR1 | |
| SCHEMBL30523334 | 0.76 | BMPR1B (0.42) | PDE1BMAPTLMNAPDE2AKDM4E | |
| SCHEMBL13644231 | 0.76 | LMNA (0.39) | PDE1BMAPTLMNAPDE2ASMN1; SMN2 | |
| SCHEMBL19354355 | 0.75 | PDE1B (0.39) | PDE1BMAPTLMNAPDE2ASMN1; SMN2 | |
| SCHEMBL30523321 | 0.75 | PDE1B (0.38) | PDE1BMAPTLMNAPDE2ASMN1; SMN2 | |
| SCHEMBL15406603 | 0.75 | MAPT (0.41) | PDE1BMAPTLMNASMN1; SMN2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761801-A | Heterocyclic compounds having protein kinase inhibitory activity, pharmaceutical compositions containing the same, and methods of preparing and using the same | 四川科伦博泰生物医药股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| WO-2022188792-A1 | HETEROCYCLIC COMPOUND HAVING PROTEIN KINASE INHIBITORY ACTIVITY, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-09-15 | — | — | WO | disclosed |