Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.53 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982216 | 0.88 | SIRT1 (0.68) | SIRT1NR1H4PLAU | |
| SCHEMBL2988125 | 0.88 | NR1H4 (0.54) | SIRT1NR1H4PLAUALOX5 | |
| SCHEMBL2992120 | 0.87 | NR1H4 (0.52) | SIRT1NR1H4PLAUALOX5 | |
| SCHEMBL2992286 | 0.85 | NR1H4 (0.53) | SIRT1NR1H4PLAU | |
| SCHEMBL2990501 | 0.85 | SALL4 (0.55) | SIRT1NR1H4PLAU | |
| SCHEMBL2979539 | 0.85 | PLAU (0.54) | SIRT1NR1H4PLAUALOX5 | |
| SCHEMBL2993500 | 0.85 | NR1H4 (0.52) | SIRT1NR1H4PLAUALOX5 | |
| SCHEMBL2975672 | 0.83 | SIRT1 (0.62) | SIRT1NR1H4PLAU | |
| SCHEMBL2987078 | 0.83 | TRIM33 (0.56) | SIRT1NR1H4PLAU | |
| SCHEMBL2989948 | 0.83 | SIRT1 (0.49) | SIRT1NR1H4PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2010-07-08 | — | — | US | claimed |
| WO-2008016648-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | claimed |
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2010-07-08 | — | — | US | disclosed |
| WO-2008016648-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | TNNC1, TNNI3, TNNT2 | SIRT1 2093/4885NR1H4 4747/4885PLAU 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.