Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL909718 | 0.78 | USP2 (0.56) | SMN1; SMN2LMNAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL533646 | 0.78 | POLB (0.97) | SMN1; SMN2POLBLMNAMAPTL3MBTL1 | |
| SCHEMBL28604242 | 0.77 | L3MBTL1 (0.53) | SMN1; SMN2POLBLMNAMAPTL3MBTL1 | |
| SCHEMBL9067293 | 0.76 | POLB (0.85) | SMN1; SMN2POLBLMNAMAPTALDH1A1 | |
| SCHEMBL15557358 | 0.76 | HTT (0.51) | SMN1; SMN2POLBLMNAMAPTL3MBTL1 | |
| SCHEMBL11037821 | 0.74 | POLB (0.87) | SMN1; SMN2POLBLMNAMAPTL3MBTL1 | |
| SCHEMBL15386968 | 0.73 | MAPT (0.47) | SMN1; SMN2LMNAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL9405372 | 0.73 | POLB (0.73) | SMN1; SMN2POLBLMNAMAPTALDH1A1 | |
| SCHEMBL30943574 | 0.73 | POLB (0.85) | SMN1; SMN2POLBLMNAMAPTL3MBTL1 | |
| SCHEMBL18672819 | 0.72 | POLB (0.84) | SMN1; SMN2POLBLMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320110-A1 | TRIAZINE DERIVATIVE AS COVALENT INHIBITORS OF PI3K | Universität Basel (CH) | 2024-02-14 | — | — | EP | disclosed |
| EP-4320115-A1 | TRIAZINE DERIVATIVE AS REVERSIBLE AND IRREVERSIBLE COVALENT INHIBITORS OF PI3K | Universität Basel (CH) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022214701-A1 | TRIAZINE DERIVATIVE AS COVALENT INHIBITORS OF PI3K | UNIVERSITÄT BASEL (CH) | 2022-10-13 | — | — | WO | disclosed |
| WO-2022214702-A1 | TRIAZINE DERIVATIVE AS REVERSIBLE AND IRREVERSIBLE COVALENT INHIBITORS OF PI3K | UNIVERSITÄT BASEL (CH) | 2022-10-13 | — | — | WO | disclosed |