Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KRAS | P01116 | 16/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23043008 | 1.00 | NPC1 (0.37) | NPC1KDM4EALDH1A1MAPK1KRAS | |
| SCHEMBL28781978 | 0.90 | KRAS (0.36) | KDM4EALDH1A1KRAS | |
| SCHEMBL29121526 | 0.79 | MAPT (0.44) | NPC1KDM4EALDH1A1POLBPKM | |
| SCHEMBL29680567 | 0.78 | NR4A2 (0.40) | KDM4EKRASNR4A2 | |
| SCHEMBL23043368 | 0.78 | NR4A2 (0.40) | KDM4EKRASNR4A2 | |
| SCHEMBL31442170 | 0.78 | ATR (0.37) | NPC1KDM4EALDH1A1MAPK1PDK1 | |
| SCHEMBL26708861 | 0.78 | AURKB (0.40) | KDM4EALDH1A1MAPK1POLB | |
| SCHEMBL28782012 | 0.76 | KRAS (0.38) | KRAS | |
| SCHEMBL22208213 | 0.71 | KDM4E (0.35) | KDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL30064964 | 0.71 | KDM4E (0.35) | KDM4EALDH1A1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025053850-A1 | COVALENT KRAS-BINDING COMPOUNDS FOR MEDICAL TREATMENT | HYKU BIOSCIENCES INC. (US) | 2025-03-13 | — | — | WO | disclosed |
| WO-2022187688-A1 | COVALENT KRAS-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |