Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583836 | 0.87 | ACLY (0.54) | ACLYAKR1C3AKR1C2KCNK2KCNK10 | |
| SCHEMBL31211855 | 0.81 | MAPK1 (0.47) | ACLYKDM4EPOLBMEN1KMT2A | |
| SCHEMBL30475489 | 0.78 | ALDH1A1 (0.46) | ACLYKDM4EL3MBTL1POLBMEN1 | |
| SCHEMBL4152400 | 0.78 | ACLY (0.54) | ACLYAKR1C3AKR1C2KCNK2KCNK10 | |
| SCHEMBL25235960 | 0.76 | KDM6B (0.56) | ACLYAKR1C3AKR1C2KCNK2KCNK10 | |
| SCHEMBL5512525 | 0.76 | KMT2A (0.51) | AKR1C3AKR1C2KDM4EMEN1KMT2A | |
| SCHEMBL6541574 | 0.76 | ALDH1A1 (0.56) | AKR1C2KDM4EMEN1KMT2AMMP1 | |
| SCHEMBL6541569 | 0.76 | ALDH1A1 (0.56) | AKR1C2KDM4EMEN1KMT2AMMP1 | |
| SCHEMBL15822564 | 0.76 | ALDH1A1 (0.56) | AKR1C2KDM4EMEN1KMT2AMMP1 | |
| SCHEMBL9942872 | 0.75 | ACLY (0.55) | ACLYAKR1C3AKR1C2KCNK2KCNK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022188735-A1 | HETEROCYCLIC COMPOUNDS AS HPK1 INHIBITORS | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2022-09-15 | — | — | WO | disclosed |