Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.49 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28361711 | 0.84 | APEX1 (0.60) | KDM4EGLAKCNK2KCNK10APEX1 | |
| SCHEMBL16632333 | 0.82 | ACLY (0.54) | ACLYKDM4EGLAKCNK2KCNK10 | |
| SCHEMBL4152400 | 0.82 | ACLY (0.54) | ACLYKDM4EGLAKCNK2KCNK10 | |
| Hydrochloric Acid SCHEMBL145407 | 0.81 | ACLY (0.53) | ACLYKDM4EGLAKCNK2KCNK10 | |
| SCHEMBL22858729 | 0.79 | ACLY (0.51) | ACLYKDM4EGLAKCNK2KCNK10 | |
| SCHEMBL10171027 | 0.79 | AKR1C3 (0.70) | ACLYKDM4EGLAKCNK2KCNK10 | |
| SCHEMBL7847232 | 0.79 | ACLY (0.59) | ACLYKDM4EGLAKCNK2KCNK10 | |
| SCHEMBL3915465 | 0.79 | ALDH1A1 (0.61) | ACLYKDM4EGLAKCNK2KCNK10 | |
| SCHEMBL9942862 | 0.79 | ABCG2 (0.52) | KDM4EGLAPOLBALDH1A1MAPT | |
| SCHEMBL9709047 | 0.78 | AKR1C3 (0.60) | ACLYGRIK1AKR1C3AKR1C2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468732-B1 | 1H-Quinazoline-2,4-diones | NOVARTIS AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| EP-2476671-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| EP-2468732-A1 | 1H-Quinazoline-2,4-diones | Novartis AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| EP-2463278-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (CH) | 2012-06-13 | — | — | EP | disclosed |