Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359212 | 1.00 | SYK (0.40) | SYKATREPHX2GABRG2GABRB3 | |
| SCHEMBL29551926 | 0.91 | SYK (0.40) | SYKATREPHX2GABRG2GABRB3 | |
| SCHEMBL29922602 | 0.84 | SYK (0.43) | SYKKMT2AMAPK1MEN1USP2 | |
| SCHEMBL28362546 | 0.84 | SYK (0.43) | SYKKMT2AMAPK1MEN1USP2 | |
| SCHEMBL28359299 | 0.82 | DHODH (0.44) | EPHX2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL29922511 | 0.82 | DHODH (0.44) | EPHX2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL28359014 | 0.79 | SYK (0.41) | SYKATRKMT2AMAPK1LMNA | |
| SCHEMBL29922810 | 0.79 | ABCB1 (0.45) | SYKKMT2AMAPK1MEN1LMNA | |
| SCHEMBL29551791 | 0.79 | SYK (0.41) | SYKATRKMT2AMAPK1LMNA | |
| SCHEMBL29922622 | 0.79 | SYK (0.43) | SYKKMT2AMAPK1MEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |