Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.69 |
| ▸ | JAK2 | O60674 | 4/20 | 0.69 |
| ▸ | JAK1 | P23458 | 4/20 | 0.69 |
| ▸ | JAK3 | P52333 | 4/20 | 0.69 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922585 | 0.90 | TYK2 (0.58) | TYK2JAK2JAK1JAK3LRRK2 | |
| SCHEMBL29922737 | 0.87 | TYK2 (0.67) | TYK2JAK2JAK1JAK3LRRK2 | |
| SCHEMBL29922670 | 0.85 | TYK2 (0.50) | TYK2JAK2JAK1JAK3CDK4 | |
| SCHEMBL28884122 | 0.82 | TYK2 (1.00) | TYK2JAK2JAK1JAK3LRRK2 | |
| SCHEMBL29922578 | 0.79 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922509 | 0.78 | TYK2 (0.52) | TYK2JAK2JAK1JAK3LRRK2 | |
| SCHEMBL29552223 | 0.76 | TYK2 (0.86) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28359052 | 0.74 | TYK2 (0.82) | TYK2JAK2JAK1JAK3MTOR | |
| SCHEMBL29922801 | 0.73 | RAB9A (0.54) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922505 | 0.73 | JAK2 (0.46) | TYK2JAK2JAK1JAK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |