Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.67 |
| ▸ | JAK2 | O60674 | 6/20 | 0.67 |
| ▸ | JAK1 | P23458 | 4/20 | 0.67 |
| ▸ | JAK3 | P52333 | 4/20 | 0.67 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 3/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922578 | 0.92 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922842 | 0.87 | TYK2 (0.69) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922509 | 0.86 | TYK2 (0.52) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29923095 | 0.83 | JAK2 (0.66) | TYK2JAK2JAK1JAK3STAT6 | |
| SCHEMBL29922801 | 0.82 | RAB9A (0.54) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922670 | 0.80 | TYK2 (0.50) | TYK2JAK2JAK1JAK3CDK4 | |
| SCHEMBL28362658 | 0.80 | TYK2 (1.00) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922585 | 0.77 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922505 | 0.76 | JAK2 (0.46) | TYK2JAK2JAK1JAK3LRRK2 | |
| SCHEMBL21384014 | 0.76 | TYK2 (0.63) | TYK2JAK2JAK1JAK3DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |