Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922936 | 0.89 | NPC1 (0.52) | RAB9ANPC1CNR2DGAT1KCNQ3 | |
| SCHEMBL29923095 | 0.83 | JAK2 (0.66) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922737 | 0.82 | TYK2 (0.67) | DGAT1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922509 | 0.81 | TYK2 (0.52) | RAB9ANPC1CNR2DGAT1JAK2 | |
| SCHEMBL29922682 | 0.80 | TYK2 (0.51) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL28362643 | 0.80 | TYK2 (0.69) | RAB9ANPC1CNR2DGAT1JAK2 | |
| SCHEMBL29552222 | 0.80 | TYK2 (0.69) | RAB9ANPC1CNR2DGAT1JAK2 | |
| SCHEMBL3124448 | 0.79 | JAK2 (0.68) | RAB9ANPC1DGAT1JAK2JAK1 | |
| SCHEMBL29922887 | 0.77 | JAK1 (0.40) | CNR2JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922706 | 0.76 | JAK2 (0.43) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |