Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21585741 | 0.80 | L3MBTL1 (0.45) | NTRK1NTRK3AKT1AKT2L3MBTL1 | |
| SCHEMBL13081603 | 0.78 | L3MBTL1 (0.47) | NTRK1NTRK3AKT1AKT2L3MBTL1 | |
| SCHEMBL10205892 | 0.78 | NTRK1 (0.58) | NTRK1NTRK3ADORA2AADORA1L3MBTL1 | |
| SCHEMBL27855202 | 0.77 | L3MBTL1 (0.42) | NTRK1NTRK3AKT1AKT2ADORA2A | |
| SCHEMBL5420324 | 0.77 | NTRK1 (0.49) | NTRK1AKT1AKT2ADORA2AADORA1 | |
| SCHEMBL6866112 | 0.77 | NTRK1 (0.49) | NTRK1NTRK3L3MBTL1MAPTNPSR1 | |
| SCHEMBL19412636 | 0.75 | CLK1 (0.37) | ALOX5ESR2KMT2ACYP2C9 | |
| SCHEMBL25490523 | 0.74 | L3MBTL1 (0.41) | NTRK1NTRK3AKT1AKT2ADORA2A | |
| SCHEMBL10555132 | 0.73 | ADORA2A (0.44) | AKT1AKT2ADORA2AADORA1L3MBTL1 | |
| SCHEMBL18371486 | 0.73 | BRS3 (0.40) | AKT2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612371-B2 | Sigma-1 receptor ligands and therapeutic uses thereof | UNIVERSITE DE STRASBOURG (FR) | 2026-04-28 | — | — | US | disclosed |
| EP-4076456-B1 | SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF | UNIV STRASBOURG (FR) | 2024-05-01 | — | — | EP | disclosed |
| US-20230076057-A1 | SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2023-03-09 | — | — | US | disclosed |
| EP-4076456-A1 | SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF | Université de Strasbourg (FR) | 2022-10-26 | — | — | EP | disclosed |
| CN-114980891-A | Sigma-1 receptor ligands and therapeutic uses thereof | 斯特拉斯堡大学 | 2022-08-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12612371-B2 | Sigma-1 receptor ligands and therapeutic uses thereof | SIGMAR1, OPRL1, OPRM1 | NTRK1 133/4885NTRK3 289/4885AKT1 1513/4885 |
| US-20230076057-A1 | SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF | SIGMAR1, OPRL1, TMEM97 | NTRK1 261/4885NTRK3 400/4885AKT1 1135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.