Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.56 |
| ▸ | JAK1 | P23458 | 3/20 | 0.56 |
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 11/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552247 | 1.00 | TYK2 (0.56) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL28358972 | 1.00 | TYK2 (0.56) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL29551800 | 0.90 | TYK2 (0.58) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL28362643 | 0.89 | TYK2 (0.69) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL29552222 | 0.89 | TYK2 (0.69) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL29922746 | 0.82 | TYK2 (0.81) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL28359040 | 0.82 | TYK2 (0.81) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL28359065 | 0.82 | DGAT1 (0.49) | RAB9ADGAT1KCNQ3KCNQ2 | |
| SCHEMBL29552105 | 0.82 | DGAT1 (0.49) | RAB9ADGAT1KCNQ3KCNQ2 | |
| SCHEMBL29922819 | 0.82 | DGAT1 (0.49) | RAB9ADGAT1KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |