Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 10/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922819 | 1.00 | DGAT1 (0.49) | DGAT1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL29552105 | 1.00 | DGAT1 (0.49) | DGAT1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL29552260 | 0.89 | MAPT (0.52) | DGAT1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL28359240 | 0.86 | JAK2 (0.52) | MAPTLMNAHTTSMN1; SMN2RAB9A | |
| SCHEMBL29922581 | 0.86 | JAK2 (0.52) | MAPTLMNAHTTSMN1; SMN2RAB9A | |
| SCHEMBL29923134 | 0.82 | TYK2 (0.56) | DGAT1RAB9AKCNQ3KCNQ2 | |
| SCHEMBL28358972 | 0.82 | TYK2 (0.56) | DGAT1RAB9AKCNQ3KCNQ2 | |
| SCHEMBL29552247 | 0.82 | TYK2 (0.56) | DGAT1RAB9AKCNQ3KCNQ2 | |
| SCHEMBL29922674 | 0.81 | INSR (0.45) | MAPTSMN1; SMN2RAB9AGAACSF1R | |
| SCHEMBL28358963 | 0.81 | INSR (0.45) | MAPTSMN1; SMN2RAB9AGAACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |