Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | HEXA | P06865 | 1/20 | 0.33 |
| ▸ | HEXB | P07686 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15148418 | 0.78 | APOBEC3A (0.38) | NOS3NOS2APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL13634487 | 0.78 | PDE4B (0.39) | APOBEC3AAPOBEC3GALDH1A1PDE4BPDE3A | |
| SCHEMBL23343508 | 0.77 | KCNH2 (0.36) | ALDH1A1TDP1HRH2HRH3TLR7 | |
| SCHEMBL25010771 | 0.76 | GRM4 (0.38) | APOBEC3AAPOBEC3GPDE4BSMN1; SMN2KDM4E | |
| SCHEMBL16802935 | 0.76 | APOBEC3A (0.34) | APOBEC3AAPOBEC3GALDH1A1PARP1PDE4B | |
| SCHEMBL5155158 | 0.76 | CHEK1 (0.44) | ALDH1A1MAPTTDP1HSD17B10SMN1; SMN2 | |
| SCHEMBL2637242 | 0.75 | PGK1 (0.49) | MBOAT4TLR8TLR7 | |
| SCHEMBL13746013 | 0.74 | NCF1 (0.42) | NOS3NOS2ALDH1A1MAPTCASP1 | |
| SCHEMBL10399548 | 0.74 | NOS3 (0.39) | NOS3NOS2ALDH1A1PARP1HEXA | |
| SCHEMBL21582525 | 0.73 | MAPT (0.39) | APOBEC3GALDH1A1MAPTCASP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334305-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236101-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY (US) | 2022-11-10 | — | — | WO | disclosed |
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |