Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TET2 | Q6N021 | 2/20 | 0.42 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM6A | O15550 | 1/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM4B | O94953 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.42 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923736 | 0.87 | PARP1 (0.66) | PARP1PDE4AALDH1A1EGLN1KDM4E | |
| SCHEMBL29923860 | 0.84 | PARP1 (0.49) | PARP1PDE4AEGLN1TDP1MAPT | |
| SCHEMBL22288232 | 0.82 | PARP1 (0.44) | PARP1PDE4AALDH1A1LMNAEGLN1 | |
| SCHEMBL21816294 | 0.80 | PSMD14 (0.56) | PARP1ALDH1A1LMNAALOX12EGLN1 | |
| SCHEMBL18484186 | 0.79 | ALDH1A1 (0.47) | PARP1PDE4AALDH1A1LMNAALOX12 | |
| SCHEMBL29923798 | 0.79 | NPC1 (0.52) | PDE4AALDH1A1LMNAEGLN1KDM4E | |
| SCHEMBL29923816 | 0.79 | EGLN1 (0.54) | PARP1EGLN1KDM4EL3MBTL1TET2 | |
| SCHEMBL29923706 | 0.79 | PARP1 (0.42) | PARP1PDE4AALDH1A1LMNAEGLN1 | |
| SCHEMBL68215 | 0.78 | ALDH1A1 (0.54) | PARP1PDE4AALDH1A1LMNAALOX12 | |
| SCHEMBL686939 | 0.78 | KDM4E (0.53) | PARP1ALOX12KDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-B1 | WDR5 INHIBITORS AND MODULATORS | UNIV VANDERBILT (US) | 2024-03-20 | — | — | EP | disclosed |
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |