Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14820315 | 0.84 | MEN1 (0.53) | ALDH1A1PDE4AKDM4ELMNAALOX12 | |
| SCHEMBL18484428 | 0.80 | ALDH1A1 (0.47) | ALDH1A1PDE4AKDM4ELMNAALOX12 | |
| SCHEMBL29923343 | 0.79 | PARP1 (0.52) | ALDH1A1PDE4AKDM4EHSD17B10LMNA | |
| SCHEMBL21816294 | 0.77 | PSMD14 (0.56) | ALDH1A1KDM4ELMNAALOX12PARP1 | |
| SCHEMBL68215 | 0.75 | ALDH1A1 (0.54) | ALDH1A1PDE4AKDM4ELMNAALOX12 | |
| SCHEMBL30605381 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAALOX12PARP1 | |
| SCHEMBL11429773 | 0.75 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNAALOX12PARP1 | |
| SCHEMBL29089214 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAALOX12PARP1 | |
| SCHEMBL4602037 | 0.74 | ALDH1A1 (0.53) | ALDH1A1KDM4ELMNAALOX12PARP1 | |
| SCHEMBL8544466 | 0.74 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10LMNAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | ALDH1A1 2837/4885PDE4A 3148/4885KDM4E 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.