Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24916496 | 1.00 | BACE1 (0.42) | BACE1POLBRAD52SMN1; SMN2GAA | |
| SCHEMBL29923623 | 0.79 | BACE1 (0.47) | BACE1GAAKMT2ACYP1A2NQO2 | |
| SCHEMBL14777091 | 0.79 | TDP1 (0.58) | BACE1POLBGAAKMT2ACYP1A2 | |
| SCHEMBL24916325 | 0.79 | BACE1 (0.47) | BACE1GAAKMT2ACYP1A2NQO2 | |
| SCHEMBL24915593 | 0.78 | LMNA (0.41) | BACE1POLBRAD52SMN1; SMN2GAA | |
| SCHEMBL24915844 | 0.77 | GRM1 (0.45) | BACE1SMN1; SMN2GAACYP1A2KDM4E | |
| SCHEMBL29923867 | 0.77 | GRM1 (0.45) | BACE1SMN1; SMN2GAACYP1A2KDM4E | |
| SCHEMBL2192977 | 0.76 | BACE1 (0.44) | BACE1GAAKMT2ACYP1A2NQO2 | |
| SCHEMBL18593905 | 0.76 | NCF1 (0.54) | BACE1POLBSMN1; SMN2GAAKMT2A | |
| SCHEMBL7551886 | 0.75 | BACE1 (0.41) | BACE1POLBKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |