Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359844 | 1.00 | TSHR (0.64) | TSHRMAPK1MAPTHSD17B10ALDH1A1 | |
| Nitrobenzene SCHEMBL11647957 | 0.88 | ALDH1A1 (0.52) | TSHRMAPK1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL30976988 | 0.83 | TSHR (0.60) | TSHRMAPK1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL400340 | 0.83 | TSHR (0.60) | TSHRMAPK1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL10893772 | 0.82 | TSHR (0.48) | TSHRMAPK1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL7862606 | 0.81 | PDE7A (0.49) | TSHRMAPK1MAPTALDH1A1LMNA | |
| SCHEMBL11859872 | 0.81 | TSHR (0.47) | TSHRMAPK1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL27782473 | 0.81 | LMNA (0.51) | TSHRMAPK1MAPTALDH1A1LMNA | |
| SCHEMBL1524058 | 0.80 | MAPK1 (0.72) | TSHRMAPK1ALDH1A1LMNAPOLB | |
| Methyl Alcohol SCHEMBL28263562 | 0.80 | TSHR (0.56) | TSHRMAPK1MAPTHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236058-A1 | CDK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| CN-112334458-B | 3-indazolinone compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-11-08 | — | — | CN | disclosed |