Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 9/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24916107 | 1.00 | KDM4E (0.38) | KDM4EL3MBTL1GRM2HTR1ASLC6A4 | |
| SCHEMBL24916497 | 0.95 | KDM4E (0.41) | KDM4EL3MBTL1GRM2HTR1ASLC6A4 | |
| SCHEMBL24915872 | 0.91 | CARM1 (0.37) | KDM4EL3MBTL1HTR1ASLC6A4CARM1 | |
| SCHEMBL24915807 | 0.84 | KDM4E (0.38) | KDM4EL3MBTL1HTR1AHSP90AA1HSP90AB1 | |
| SCHEMBL29923349 | 0.84 | KDM4E (0.38) | KDM4EL3MBTL1HTR1AHSP90AA1HSP90AB1 | |
| SCHEMBL24916031 | 0.83 | KDM4E (0.36) | KDM4EL3MBTL1SLC6A4HSP90AA1HSP90AB1 | |
| SCHEMBL29923321 | 0.80 | NSD2 (0.38) | KDM4EHTR1AHSP90AA1HSP90AB1NSD2 | |
| SCHEMBL24916137 | 0.80 | NSD2 (0.38) | KDM4EHTR1AHSP90AA1HSP90AB1NSD2 | |
| SCHEMBL24916038 | 0.79 | KDM4E (0.40) | KDM4EL3MBTL1HTR1ASLC6A4HSP90AA1 | |
| SCHEMBL24916306 | 0.79 | CYP19A1 (0.38) | KDM4EHSP90AA1HSP90AB1NSD2CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |