Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17667850 | 0.79 | CHKA (0.44) | KDM4ECHKANCF1 | |
| SCHEMBL4982315 | 0.79 | CSF1R (0.43) | CSF1RADRA2CHTR3AGAAKDM4E | |
| SCHEMBL3080128 | 0.73 | MAPT (0.52) | CSF1RKITPSMB5PSMB1ADRA2C | |
| SCHEMBL3587531 | 0.73 | ADRA2C (0.49) | ADRA2CHTR3AGAAKDM4EMAPT | |
| SCHEMBL4101892 | 0.70 | HRH4 (0.47) | ADRA2CHTR3AGAAKDM4EHRH4 | |
| SCHEMBL4984976 | 0.70 | HRH4 (0.41) | ADRA2CHTR3AGAAKDM4EMAPT | |
| SCHEMBL5884761 | 0.70 | HTR3A (0.51) | ADRA2CHTR3AGAAKDM4EMAPT | |
| SCHEMBL15400291 | 0.69 | MAPT (0.40) | CSF1RADRA2CHTR3AGAAKDM4E | |
| SCHEMBL2935698 | 0.69 | SIRT6 (0.56) | CSF1RKITMAPTMAPK1ALDH1A1 | |
| SCHEMBL2912399 | 0.69 | CSF1R (0.54) | CSF1RKITPSMB5PSMB1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222298-A1 | USE OF CFMS INHIBITOR FOR TREATING OR PREVENTING BONE CANCER AND THE BONE LOSS AND BONE PAIN ASSOCIATED WITH BONE CANCER | Janssen Pharmaceutica N.V. (BE) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009058801-A1 | USE OF CFMS INHIBITOR FOR TREATING OR PREVENTING BONE CANCER AND THE BONE LOSS AND BONE PAIN ASSOCIATED WITH BONE CANCER | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-07 | — | — | WO | disclosed |