Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 7/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29424063 | 0.85 | MAPT (0.46) | MAPTALDH1A1TP53HPGDHTT | |
| SCHEMBL29150127 | 0.83 | HCRTR2 (0.39) | MAPTHTTHTR2AHTR2CHTR2B | |
| SCHEMBL23980935 | 0.82 | CYP11B1 (0.39) | HPGDHTR2AHTR2CHTR2BNPC1 | |
| SCHEMBL24186456 | 0.82 | HTR2A (0.37) | MAPTALDH1A1TP53HPGDHTT | |
| SCHEMBL23980833 | 0.82 | HTR2A (0.37) | MAPTALDH1A1TP53HPGDHTT | |
| SCHEMBL29924349 | 0.82 | HTR2A (0.37) | MAPTALDH1A1TP53HPGDHTT | |
| SCHEMBL30275367 | 0.82 | CYP11B1 (0.39) | HPGDHTR2AHTR2CHTR2BNPC1 | |
| SCHEMBL24969521 | 0.82 | MAPT (0.43) | MAPTALDH1A1TP53HPGDHTT | |
| SCHEMBL28949266 | 0.82 | ADRA2A (0.52) | HTR2AHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL30217488 | 0.82 | ADRA2A (0.52) | HTR2AHTR2CHTR2BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568664-A1 | COMBINATION COMPRISING A THR-BETA AGONIST AND A GLP-1R AGONIST FOR USE IN TREATING A LIVER DISORDER OR A CARDIOMETABOLIC DISEASE | Terns Pharmaceuticals, Inc. (US) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024211898-A1 | COMBINATION COMPRISING A THRBETA AGONIST ANDA GLP-1R AGONIST FOR USE IN TREATING A LIVER DISORDER OR A CARDIOMETABOLIC DISEASE | TERNS PHARMACEUTICALS, INC. (US) | 2024-10-10 | — | — | WO | disclosed |
| WO-2022228490-A1 | POLYCYCLIC DERIVATIVE MODULATOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2022-11-03 | — | — | WO | disclosed |