Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 6/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27032273 | 1.00 | ATR (0.43) | ATRBRD4DNMT3ASUCNR1CA12 | |
| SCHEMBL29925841 | 0.91 | ATR (0.45) | ATRBRD4SUCNR1CA12CA1 | |
| SCHEMBL27032041 | 0.91 | ATR (0.45) | ATRBRD4SUCNR1CA12CA1 | |
| SCHEMBL27032631 | 0.83 | ATR (0.47) | ATRBRD4CA12CA1CA2 | |
| SCHEMBL30971862 | 0.78 | KDR (0.37) | DNMT3A | |
| SCHEMBL24013151 | 0.78 | BRD4 (0.41) | BRD4DNMT3A | |
| SCHEMBL29925614 | 0.77 | HTR3A (0.38) | ATR | |
| SCHEMBL27031960 | 0.77 | HTR3A (0.38) | ATR | |
| SCHEMBL4129083 | 0.76 | ATR (0.43) | ATR | |
| SCHEMBL29925916 | 0.76 | MEN1 (0.36) | ATRPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |