Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 7/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29927883 | 0.83 | AXL (0.51) | AXLINSRHTTKDRATM | |
| SCHEMBL29927676 | 0.74 | ATM (0.69) | AXLINSRKDRATMPIK3CA | |
| SCHEMBL4997739 | 0.72 | AXL (0.73) | AXLINSRKDR | |
| SCHEMBL4990541 | 0.72 | AXL (0.54) | AXLINSRHTTKDR | |
| SCHEMBL3337904 | 0.70 | MAP4K4 (0.68) | NR4A2CYP1A2CYP2D6MAP4K4 | |
| SCHEMBL29793572 | 0.69 | PDE4A (0.57) | HTTNR4A2CYP1A2CYP2D6MAP4K4 | |
| SCHEMBL856909 | 0.69 | PDE4A (0.57) | HTTNR4A2CYP1A2CYP2D6MAP4K4 | |
| SCHEMBL29928021 | 0.69 | KDR (0.50) | AXLHTTKDRPIK3CAPIK3CB | |
| SCHEMBL29928613 | 0.69 | HTR2C (0.47) | AXLINSRKDRATMPIK3CA | |
| SCHEMBL28164190 | 0.68 | ALDH1A1 (0.43) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | claimed |
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |