Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846685 | 0.85 | MAPT (0.37) | MAPTTDP1L3MBTL1SLC29A1SMN1; SMN2 | |
| SCHEMBL4045936 | 0.79 | EGFR (0.53) | MAPTTDP1ALDH1A1EGFRAPP | |
| SCHEMBL2980671 | 0.76 | ALDH1A1 (0.38) | MAPTTDP1L3MBTL1SLC29A1SMN1; SMN2 | |
| SCHEMBL13322079 | 0.74 | HIF1A (0.41) | HIF1AAPP | |
| SCHEMBL15277464 | 0.73 | APP (0.63) | MAPTTDP1ALDH1A1EGFRAPP | |
| SCHEMBL1828406 | 0.72 | MAPT (0.47) | MAPTTDP1L3MBTL1SMN1; SMN2CYP3A4 | |
| SCHEMBL13267383 | 0.72 | MAPT (0.47) | MAPTTDP1L3MBTL1SMN1; SMN2CYP3A4 | |
| SCHEMBL3422229 | 0.71 | APP (0.60) | SMN1; SMN2EGFRAPPPDE5A | |
| SCHEMBL3391705 | 0.71 | APP (0.61) | CYP2D6NPC1ALDH1A1HTTEGFR | |
| SCHEMBL4916234 | 0.70 | SLC29A1 (0.51) | SLC29A1NPC1ALDH1A1HTTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173914-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. | 2010-07-08 | — | — | US | disclosed |
| US-20100173914-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. | 2010-07-08 | — | — | US | disclosed |
| US-20100173914-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. | 2010-07-08 | — | — | US | disclosed |
| US-20100130515-A1 | Polymorphs and solvates of a pharmaceutical and method of making | BIOGEN IDEC INC. (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130515-A1 | Polymorphs and solvates of a pharmaceutical and method of making | BIOGEN IDEC INC. (US) | 2010-05-27 | — | — | US | disclosed |
| EP-2117313-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008088927-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008088927-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130515-A1 | Polymorphs and solvates of a pharmaceutical and method of making | CYP3A7, CYP2D6, CYP3A5 | MAPT 980/4885TDP1 164/4885L3MBTL1 2986/4885 |
| US-20100173914-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | ADORA2A, P2RY1, P2RY6 | MAPT 4330/4885TDP1 938/4885L3MBTL1 4761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.