Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846685 | 0.92 | MAPT (0.37) | ALDH1A1CYP3A4MAPTTDP1L3MBTL1 | |
| SCHEMBL2982269 | 0.85 | APP (0.43) | MAPTNPC1SMN1; SMN2LMNAGAA | |
| SCHEMBL2992876 | 0.76 | MAPT (0.41) | ALDH1A1CYP3A4MAPTTDP1L3MBTL1 | |
| SCHEMBL13244946 | 0.75 | APP (0.52) | SMN1; SMN2EGFRPDE5A | |
| SCHEMBL2984748 | 0.65 | ADORA2A (0.50) | ALDH1A1CYP3A4TSHRRECQLKMT2A | |
| SCHEMBL10039247 | 0.65 | KMT2A (0.51) | ALDH1A1CYP3A4TSHRRECQLMAPT | |
| SCHEMBL5175689 | 0.65 | TLR8 (0.55) | L3MBTL1 | |
| SCHEMBL1225410 | 0.65 | ALDH1A1 (0.53) | ALDH1A1CYP3A4TSHRRECQLMAPT | |
| SCHEMBL4045936 | 0.65 | EGFR (0.53) | ALDH1A1TSHRMAPTTDP1MEN1 | |
| SCHEMBL26795931 | 0.64 | GHSR (0.44) | ALDH1A1MAPTNPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173914-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. | 2010-07-08 | — | — | US | disclosed |
| EP-2117313-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008088927-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173914-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | ADORA2A, P2RY1, P2RY6 | ALDH1A1 1852/4885CYP3A4 1116/4885TSHR 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.